GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UCEC | cis | rs1577917 | 1 | rs955227 | chr6:86651032 | SNHG5 | chr6:86386726-86388451:- | -0.54 | -5.86 | 2.78E-8 | Response to antipsychotic treatment |
| UCEC | cis | rs1577917 | 1 | rs9647603 | chr6:86639341 | SNHG5 | chr6:86386726-86388451:- | -0.46 | -5.96 | 1.65E-8 | Response to antipsychotic treatment |
| UCEC | cis | rs9309473 | 1 | rs9653557 | chr2:73795962 | ALMS1P | chr2:73872046-73912692:+ | 0.47 | 5.52 | 1.45E-7 | Metabolite levels |
| UCEC | cis | rs9894429 | 1 | rs9674872 | chr17:79581931 | TSPAN10 | chr17:79609349-79615778:+ | 0.67 | 8.58 | 1.03E-14 | Eye color traits |
| UCEC | cis | rs9894429 | 1 | rs9747349 | chr17:79584297 | TSPAN10 | chr17:79609349-79615778:+ | 0.66 | 8.57 | 1.11E-14 | Eye color traits |
| UCEC | cis | rs9894429 | 1 | rs9748176 | chr17:79584043 | TSPAN10 | chr17:79609349-79615778:+ | 0.69 | 8.81 | 2.73E-15 | Eye color traits |
| UCEC | cis | rs10935120 | 1 | rs9809619 | chr3:134280948 | ANAPC13 | chr3:134196547-134204865:- | 0.4 | 4.65 | 7.03E-6 | Height |
| UCEC | cis | rs10935120 | 1 | rs9813774 | chr3:134227100 | ANAPC13 | chr3:134196547-134204865:- | 0.4 | 4.62 | 8.08E-6 | Height |
| UCEC | cis | rs9815354 | 1 | rs9815354 | chr3:41912651 | ULK4 | chr3:41288091-42003660:- | 0.43 | 4.44 | 1.7E-5 | Diastolic blood pressure |
| UCEC | cis | rs9815354 | 1 | rs9818169 | chr3:41860599 | ULK4 | chr3:41288091-42003660:- | 0.45 | 5.21 | 6.03E-7 | Diastolic blood pressure |
| UCEC | cis | rs10935120 | 1 | rs9819532 | chr3:134288644 | ANAPC13 | chr3:134196547-134204865:- | 0.41 | 4.69 | 6.01E-6 | Height |
| UCEC | cis | rs9815354 | 1 | rs9820192 | chr3:41889281 | ULK4 | chr3:41288091-42003660:- | 0.52 | 6.25 | 3.94E-9 | Diastolic blood pressure |
| UCEC | cis | rs9815354 | 1 | rs9825741 | chr3:41761828 | ULK4 | chr3:41288091-42003660:- | -0.49 | -6.02 | 1.24E-8 | Diastolic blood pressure |
| UCEC | cis | rs9815354 | 1 | rs9826058 | chr3:41762062 | ULK4 | chr3:41288091-42003660:- | 0.52 | 6.41 | 1.76E-9 | Diastolic blood pressure |
| UCEC | cis | rs10935120 | 1 | rs9826496 | chr3:134224437 | ANAPC13 | chr3:134196547-134204865:- | 0.4 | 4.56 | 1.04E-5 | Height |